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Cell Migration / Invasion in Development and Cancer


Instructor: David Sherwood
Summary: Cell migration/invasion through extracellular matrix and tissues play crucial roles in the development, maintenance and regeneration of multicellular organisms. Inappropriate and defective cell migration also underlies numerous diseases, including inflammatory diseases (i.e. asthma, rheumatoid arthritis, multiple sclerosis, psoriasis and Crohn′s disease), developmental disorders, and tumor spread. Understanding cell migration is also important for regenerative therapies, including stem-cell grafting, where defective migration/invasion is a major limitation. Cell migration takes on a variety of forms, and this course covers how cells migrate and invade as individuals, in groups as well as the plasticity of migration modes in development and cancer.


Plasticity of cell migration: a multiscale tuning model. Friedl P, Wolf K. J., Cell Biol. 2010 Jan 11;188(1):11-9. doi: 10.1083/jcb.200909003. Epub 2009 Dec 1.