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Genetic Switches and Oscillators


Instructor: Nicolas Buchler
Summary: Genetic switches and oscillators are essential for proper patterning, cell proliferation, and cellular differentiation in biological systems. This "systems biology" module will cover the underlying principles behind epigenetic switches (bistability) and clocks (oscillators) in gene networks. I will also discuss the origins and consequences of molecular noise in biological networks. My goal is to make you literate enough to read a "systems biology" paper, understand how the authors transform a biochemical model into equations, and use basic computer simulations to run and critically evaluate the modeling conclusions. This module will require an understanding of calculus (derivatives, integrals).


Molecular Biology of the Cell, Alberts et al., - Chapter 7 (Control of Gene Expression, all sections up to Post-transcriptional Controls)