Our research focuses on the area of cell cycle control, and in particular how it interacts with control of cell polarity. One focus is the study of how changes in the activity of the Cyclin Dependent Kinases (CDKs) that control cell cycle progression promote specific changes in the organization of the actin cytoskeleton. A second focus involves investigation of a novel checkpoint control that monitors the organization of the actin cytoskeleton. When environmental insults disrupt actin organization, this checkpoint delays entry into mitosis through inhibition of CDK/cyclin kinases. Trainees use genetic and biochemical approaches to study these signaling pathways in the experimentally tractable budding yeast.
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