We are interested in how developing cells make "decisions" about
their differentiation fate. Studies are conducted at a variety of levels, from molecular
biological events controlling cell replication and differentiation,
through the determination of cell fate, and where the nervous
system is concerned, synapse formation and physiological
function. Ongoing projects comprise three areas:
- the role of
endocrine and neurotrophic factors in gene expression by
developing neurons and endocrine-sensitive cancer cells;
- effects
of drugs of abuse (nicotine, cocaine), environmental contaminants
(especially pesticides) and hormonal imbalances on brain cell
development; and
- neural control of fetal/neonatal cardiovascular
and respiratory function, with special emphasis on Sudden Infant
Death Syndrome.
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