| Alejandro Aballay |
Assistant Professor of Molecular
Genetics & Microbiology |
Innate Immunity and Microbial Pathogenesis |
| Soman Abraham |
Professor of Pathology |
Mechanisms and consequences of the molecular interactions
occurring between pathogenic bacteria and inflammatory
cells. |
| Hubert Amrein |
Assistant Professor of Molecular
Genetics & Microbiology |
Role and function of roX RNAs in Drosophila
dosage compensation and functional analysis of Drosophila odorant
receptor proteins |
| Vadim
Arshavsky |
Professor of Neurobiology |
Signal transduction in vertebrate rod and cone photoreceptors. |
| Maki Asano |
Assistant Research Professor of Molecular
Genetics & Microbiology |
Regulation of DNA replication and the cell cycle. |
| George Augustine |
George Barth Gellar Professor of Neurobiology |
Neuronal signaling pathways; molecular mechanisms
of synaptic exocytosis and plasticity. |
| Michael
Been |
Professor of Biochemistry |
Hepatitis Delta Virus Self-cleaving RNA. |
| Lorena Beese |
Professor of Biochemistry |
Structure and mechanism of proteins and macromolecular
assemblies central to DNA replication, DNA repair,
and cellular signaling. X-ray crystallography. Structure-based
drug design. Cancer biology. |
| Amy Bejsovec |
Associate Professor of Biology |
Specification of cell fates during Drosophila development,
the role of intercellular signaling in pattern formation
and oncogenic processes. |
| Philip Benfey |
Professor of Biology |
Plant Developmental Genetics and Genomics |
| Vann Bennett |
James B. Duke Professor of Cell
Biology |
Membrane-cytoskeletal interactions in mammalian brain
and other tissues. |
| Darrell Bigner |
Professor of Pathology |
Neuropathology; viral oncology; chemical carcinogenesis. |
| Perry Blackshear |
Professor of Biochemistry |
Messenger RNA turnover in cytokine biosynthesis;
protein kinase C and brain development. |
| Gerard Blobe |
Assistant Professor of Pharmacology
and Cancer Biology |
Cancer biology, vascular biology, signal
transduction, TGF-beta signaling pathway, cellular
trafficking |
| Celia Bonaventura |
Professor of Cell Biology at the Nicholas
School of the Environment |
Cell Biology: Equilibria & Reaction
Kinetics in Red Cells & Hemoglobins. Biochemistry:
Structure- Function Relationships in Respiratory Proteins.
Structural Biology: Protein Dynamics & Protein
Engineering |
| Rose-Mary Boustany |
Professor of Neurobiology |
Mechanisms of apoptosis in neurodegeneration and
cancer. |
| Nicole Calakos |
Assistant Professor of Neurobiology |
Molecular basis of
synaptic plasticity; presynaptic function; basal ganglia
function and pathology. |
| Blanche
Capel |
Professor of Cell
Biology |
Sex determination; ovary and testis organogenesis;
germ cell biology; vascular development. |
| Maria
Cardenas-Corona |
Associate Research Professor of Molecular
Genetics & Microbiology |
Mechanisms of Signaling by the targets of rapamycin:
the TOR kinases. |
| Marc Caron |
Professor of Cell
Biology |
Molecular mechanisms of hormone and neurotransmitter
actions and regulation of cellular responsiveness. |
| Patrick Casey |
James B. Duke Professor of Pharmacology
and Cancer Biology |
Cellular signalling mediated through GTP-binding
proteins; lipid modifications of proteins. |
| Jen-Tsan Ashley Chi |
Assistant Professor f Molecular
Genetics & Microbiology |
Genomic approaches to analyze biological systems
and disease |
| Dona Chikaraishi |
Professor of Neurobiology |
Molecular regulation of catecholamine neurotransmitter
biosynthesis and function. |
| Christopher Counter |
Associate Professor of Pharmacology
and Cancer Biology |
Molecular mechanism of tumorigenesis. |
| Gregory Crawford |
Assistant Professor of Genetics and
Genomics |
Genome-wide identification and characterization
of gene regulatory elements |
| Bryan Cullen |
Professor of Molecular
Genetics & Microbiology |
Molecular genetics of HIV gene regulation. |
| Michael
B. Datto |
Assistant Professor of Pathology |
Mechanisms of cell type specific and context dependent
TGF-β Signal Transduction. |
| Fred Dietrich |
Associate Professor of Molecular
Genetics & Microbiology
|
Genetics and Genomics of fungal pathogens and of
Saccharomyces cerevisiae. |
| Xinnian Dong |
Professor of Biology |
Response of plants to pathogens; molecular and genetic
investigation of the signal transduction pathways activating
plant defense genes. |
| Michael
Ehlers |
Associate Professor of Neurobiology |
Protein trafficking and turnover in neuronal dendrites;
Cell biology of the postsynaptic membrane; Molecular
regulation of excitatory synaptic transmission. |
| Sharyn Endow |
Professor of Cell
Biology |
Microtubule motor proteins involved in spindle function;
chromosome movement in meiosis and mitosis. |
| Harold Erickson |
Professor of Cell
Biology |
Cytoskeleton and cell motility in eukaryotes and
bacteria; cell adhesion and extracellular matrix. |
| Guoping
Feng |
Assistant Professor of Neurobiology |
Molecular mechanisms regulating synapse formation; synaptic and circuitry basis of behavior and its implications in neuropsychiatric disorders. |
| Paulo Ferreira |
Associate Professor of Molecular
Genetics & Microbiology |
Molecular, genetic and cellular basis of neurodystrophies
and allied systemic disorders; dynamic assembly of
protein complexes in signaling and trafficking pathways. |
| Rodney Folz |
Assistant Research Professor of Cell
Biology |
Molecular and cellular biology of oxidant and antioxidant
systems with an emphasis on extracellular compartments
and lung biology / physiology. |
| Mariano
Garcia-Blanco |
Professor of Molecular
Genetics & Microbiology |
Synthesis and maturation of messenger RNAs in the
nucleus of cells. |
| Arno Greenleaf |
Professor of Biochemistry |
Enzymology of gene expression: 1) CTD kinase and
RNA polymerase II hyperphosphorylation; 2) PhosphoCTD-associating
proteins and organization of nuclear functions. |
| Matthias Gromeier |
Assistant Professor of Molecular
Genetics & Microbiology |
Translation Control, Internal Ribosomal Entry, Virology,
Vaccine Development, Neuro-Oncology, Cancer, Therapeutics,
Oncolytic Viruses, Hepatitis C Virus. |
| Steve
Haase |
Assistant Professor of Biology |
Genetic, genomic, molecular, and cellular approaches
to understanding cell cycle regulation in yeast. Cyclin
dependent kinase control of centrosome duplication. |
| Laura Hale |
Assistant Professor of Pathology |
Thymic biology. Immune function in normal
aging, cancer, and autoimmunity. |
| Barton Haynes |
Professor of Immunology |
Study of human T cell maturation and
thymus biology; biology of human retroviruses; autoimmune
disease. |
| You-Wen He |
Associate Professor of Immunology |
T lymphocyte development and apoptosis.
Innate immune response. T lymphocyte memory formation. |
| Joseph Heitman |
James B. Duke Professor of Molecular
Genetics & Microbiology |
Signaling cascades regulating filamentous growth
and virulence of yeast and pathogenic fungi. Genetic
analysis of immunosuppressive drug action. |
| Homme Hellinga |
Professor of Biochemistry |
Combined theoretical and experimental approaches
to protein and drug design; molecular simulation; protein
engineering. |
| Michael Hershfield |
Professor of Biochemistry |
Genetic and biochemical studies of inherited diseases
of purine metabolism. |
| Brigid Hogan |
Professor of Cell
Biology |
Mammalian development and organogenesis; primordial
germ cells and stem cells. |
| Tao-shih Hsieh |
Professor of Biochemistry |
Chromosome structure and function; structure, function,
and mechanism of DNA topoisomerase. |
| Randy
Jirtle |
Professor of Pathology |
Epigenetic basis of human disease. |
| William
Kane |
Associate Professor of Pathology |
Molecular biology of blood coagulation factor V and
thrombosisT. Structure, function and regulation of
the prothrombinase complex. |
| Jack Keene |
Professor of Molecular
Genetics & Microbiology |
Functions of RNA-binding proteins in coordinating
the global regulation of gene expression during homeostasis
and disease. |
| Daniel Kenan |
Assistant Professor of Pathology |
Tumor vascular biology, regulation of
gene expression, tissue engineering. |
| Daniel Kiehart |
Professor of Biology |
Mechanism and regulation of cellular movements and
shape changes during metazoan development (morphogenesis). |
| John Klingensmith |
Associate Professor of Cell
Biology |
Molecular genetics of mammalian development and birth
defects. |
| Motonari Kondo |
Assistant Professor of Immunology |
Commitment of hematopoietic stem cells, lymphocyte
development, cytokine receptor signaling. |
| Sally Kornbluth |
Professor of Pharmacology
and Cancer Biology |
Regulation of apoptosis and control of mitotic entry. |
| Michael Krangel |
Professor of Immunology |
V(D)J recombination; chromatin structure;
developmental regulation of T cell receptor genes. |
| Virginia Kraus |
Associate Professor of Pathology |
Molecular pathogenesis of arthritis; genetics of
osteoarthritis; metalloproteinases. |
| William Kraus |
Assistant Professor of Cell
Biology |
Skeletal muscle gene regulation in exercise physiology
and disease. In vivo (human and animals) and in vitro
work. Human genetics. |
| Ken Kreuzer |
Professor of Biochemistry |
Mechanisms of DNA replication, recombination and
repair, and the interconnections between these processes. |
| Meta Kuehn |
Associate Professor of Biochemistry |
Biochemical and genetic analysis of secretory outer
membrane vesicles produced by pathogenic bacteria. |
| Cynthia Kuhn |
Professor of Pharmacology
and Cancer Biology |
Gonadal steroid action in the brain. |
| Madan Kwatra |
Associate Professor of Pharmacology
and Cancer Biology |
Signal transduction through G Protein-coupled receptors;
aging. |
| Terry Lechler |
Assistant Professor of Cell
Biology |
Development and morphogenesis of two highly proliferative
tissues, the skin and the intestine. |
| Robert
Lefkowitz |
James B. Duke Professor of Neurobiology |
Elucidation of the molecular properties and regulatory
mechanisms controlling the function of G protein-coupled
receptors. |
| Daniel Lew |
Professor of Pharmacology
and Cancer Biology |
Cell cycle control and the control of
cell polarity. |
| Wolfgang Liedtke |
Assistant Professor of Neurobiology |
Molecular mechanisms of neuro-sensory
transduction in response to osmotic and mechanical
stimuli. |
| Elwood Linney |
Professor of Molecular
Genetics & Microbiology |
Molecular approaches to retinoic acid and estrogen
signaling during zebrafish embryonic development; 3D
immaging of gene expression; environmental biosensing
using embryos. |
| Donald Lo |
Associate Professor of Neurobiology |
Translation of basic neuroscience research into the
identification new drug candidates and targets for
neuropsychiatric diseases including Alzheimer's disease,
Huntington's disease, stroke, and glaucoma. |
| Micah Luftig |
Assistant Professor, Molecular Genetics and Microbiology |
Mechanisms of viral oncogenesis and host response to oncogenic virus infection |
| David MacAlpine |
Assistant Professor of Pharmacology and Cancer Biology |
Genomic approaches to understanding how the molecular architecture
of
the
chromosome regulates DNA replication. |
| Douglas
Marchuk |
Professor of Molecular
Genetics & Microbiology |
Molecular genetics and cell biology of inherited
human disease, with particular emphasis on the cardiovascular
system. |
| Jeffrey Marks |
Assistant Professor of Pathology |
Investigation of the etiology and progression of
breast and ovarian cancer. |
| Hiroaki Matsunami |
Assistant Professor of Molecular
Genetics & Microbiology |
Molecular mechanisms underlying odorant and pheromone
recognition in mammals |
| David McClay |
Arthur S. Pearse Professor of Biology |
Germ layer specification, gene regulatory
networks, adhesion at gastrulation, and patterning
cues during morphogenesis. |
| John McCusker |
Associate Professor of Molecular
Genetics & Microbiology |
Genetic and molecular analysis of fungal pathogenesis. |
| Donald McDonnell |
Glaxo Wellcome Professor of Pharmacology
and Cancer Biology |
The progesterone, estrogen and androgen
receptor signaling pathways are complex and provide
a wealth of opportunities for new drug discovery. |
| Thomas McIntosh |
Professor of Cell
Biology |
Membrane structure; membrane rafts; peptide-lipid
interactions. |
| James McNamara |
Professor of Neurobiology |
Molecular mechanisms of epileptogenesis. |
| Anthony Means |
Nanaline H. Duke Professor of Pharmacology
and Cancer Biology |
Intracellular signaling pathways that affect cell
cycle progression; calcium receptor functions. |
| Thomas Mitchell |
Associate Professor of Molecular
Genetics & Microbiology |
Medical mycology; molecular mechanism of fungal pathogenesis;
populaiton genetics of pathogenic yeasts. |
| Paul Modrich |
James B. Duke Professor of Biochemistry |
Mechanisms of DNA repair and recombination; DNA repair
defects in tumor development and drug resistance. |
| Richard Mooney |
Associate Professor of Neurobiology |
Neural mechanisms of learning and memory, especially
the regulation at the cellular level for learned vocalizations
in songbirds. |
| Joseph
Nevins |
James B. Duke Professor of Molecular
Genetics & Microbiology |
Gene regulation during cell growth and
oncogenesis. |
| Christopher
Nicchitta |
Associate Professor of Cell
Biology |
Protein and mRNA trafficking. Chaperone immunobiology. |
| R. Bruce Nicklas |
Arthur S. Pearse Professor of Biology |
Chromosome movement in mitosis. |
| Terrence
Oas |
Associate Professor of Biochemistry |
Protein folding; folding-related determinants of
protein function, statistical mechanical modelling
of conformational transitions, ribonucleoprotein assembly. |
| Edward
Patz |
Professor of Pharmacology
and Cancer Biology |
Development of new molecular diagnostics including
protein biomarkers and molecular imaging approaches. |
| Thomas Petes |
Professor and Chair of Molecular
Genetics and Microbiology |
Genetic regulation of genome stability in yeast;
meiotic recombination |
| Zhen-Ming Pei |
Assistant Professor of Biology |
Calcium and nitric oxide signaling in Arabidopsis. |
| Ann Marie
Pendergast |
Professor of Pharmacology
and Cancer Biology |
Role of tyrosine kinases and associated
adaptor proteins in the regulation of normal development
and pathological conditions, including cancer, bacterial
pathogenesis, muscular dystrophies, and immune deficiencies. |
| David Pickup |
Associate Professor of Molecular
Genetics & Microbiology |
Molecular mechanisms of viral pathogenesis, particularly
viral modification of host cytokine-responses to infection. |
| Salvatore Pizzo |
Professor of Pathology |
Fibrinolysis; antigen presentation; proteinase inhibitors. |
| Kenneth Poss |
Assistant Professor of Cell
Biology |
Modeling disease and regeneration in zebrafish. |
| Christian
Raetz |
George B. Geller Professor of Biochemistry |
Membrane biochemistry; molecular genetics and bioinformatics
of lipid synthesis; structure, biosynthesis and function
of bacterial endotoxins; structural lipidomics. |
| Jeffrey Rathmell |
Assistant Professor of Pharmacology
and Cancer Biology |
Molecular and metabolic
mechanisms of lymphocyte growth and apoptosis. |
| Tannishtha Reya |
Assistant Professor of Pharmacology
and Cancer Biology |
Regulation of Hematopoietic Stem Cell
Self-renewal and Commitment. |
| Jeremy Rich |
Assistant Professor of Neurobiology |
Signal transduction in brain tumors. The contribution
of cancer stem cells to therapeutic resistance. |
| David Richardson |
Professor of Biochemistry |
X-ray crystallography of globular proteins;
design of protein structure. |
| Jane Richardson |
Professor of Biochemistry |
Patterns of protein folding; X-ray crystallography;
design of protein structure. |
| Sue Robertson |
Associate Professor of Molecular Genetics and Microbiology |
Regulation of genome stability in yeast; homologous recombination
and mutagenesis. |
| Howard Rockman |
Associate Professor of Cell
Biology |
Molecular mechanisms of hypertrophy
and heart failure using transgenic and gene targeted
mouse models. |
| Laura Rusche |
Assistant Professor of Biochemistry |
Chromatin-mediated repression of transcription. |
| Marcella
Sarzotti-Kelsoe |
Assistant Research Professor of Immunology |
The manipulation of immune responses
to virus in the neonatal susceptible host which can
induce long-lasting immunity. |
| Fred Schachat |
Associate Professor of Cell
Biology |
Molecular biology of contractile protein expression
and function. |
| Patrick C. Seed |
Assistant Professor of Molecular Genetics and Microbiology |
Elucidating the Molecular Pathogenesis of Urinary Tract Infections. |
| Greg Sempowski |
Assistant Research Professor of Pathology |
Mechanisms that regulate T cell production and peripheral
homeostasis. Development of novel therapeutics to improve
T cell immune recovery and function. |
| David Sherwood |
Assistant Professor of Biology |
Genetic and molecular analysis of cell-invasion
in C. elegans |
| James Siedow |
Professor of Biology |
Biochemical & molecular studies of oxidative
processes in plants using the cyanide-resistant, alternative
oxidase associated with plant mitochodria; effect of
the fungal phytotoxins on the structure and permeability
of mitochondrial membranes. |
| Sidney Simon |
Professor of Neurobiology |
Mechanisms of chemical induced pain, inflammation
and taste; molecular peptide-lipid interactions. |
| J.H. Pate Skene |
Associate Professor of Neurobiology |
Neuronal development and axon growth; regulation
of transcription; protein palmitoylation as a regulatory
mechanism. |
| Theodore Slotkin |
Professor of Pharmacology and Cancer Biology |
Developmental neurobiology, neuropharmacology and neurotoxicology. |
| Scott Soderling |
Assistant Professor of Cell
Biology |
Signaling mechanisms that regulate cell migration,
neurite outgrowth, synapse formation, animal behavior;
roles of Rho GTPase Activating Proteins in signaling
to the actin cytoskeleton. |
| Leonard Spicer |
Professor of Biochemistry |
Structure-function studies of proteins using high
field NMR techniques; Biophysical characterization
of the MetJ transcription regulation complex and the
excision nuclease, DNA repair assembly. |
| Herman Staats |
Associate Professor of Pathology |
Identifying and characterizing novel mucosal adjuvants
and their mechanism of action, defining the mechanisms
that control the specificity of vaccine-induced serum
igg and mucosal iga, and optimizing nasal immunization
in non-human primates. |
| Deborah Steege |
Professor of Biochemistry |
Posttranscriptional control; translational regulation
and coupling; mRNA processing and decay. |
| Joseph W. St. Geme |
Professor of Molecular Genetics and Microbiology |
Molecular and cellular determinants of bacterial pathogenesis, bacterial
adherence and invasion, bacterial protein secretion,
Haemophilus and Kingella pathogenicity, vaccine development. |
| Bruce Sullenger |
Associate Professor of Molecular
Genetics & Microbiology |
Development of RNA-based therapeutics. |
| Beth Sullivan |
Assistant Professor of Molecular Genetics and Microbiology |
Epigenetic/epigenomic mechanisms of chromosome structure and
function, centromere and heterochromatin organization,
and genome stability. |
| Tai-ping Sun |
Professor of Biology |
Molecular genetics of plant growth hormones; environmental
and developmental regulation of gibberellin biosynthesis
and signal transduction. |
| Thomas
Tedder |
Alter Geller Professor of Immunology |
Structure and function of human leukocyte adhesion
molecules; B lymphocyte activation. |
| Dennis Thiele |
Professor of Pharmacology
and Cancer Biology |
Molecular biology and genetics of iron and copper
in growth and development; stress gene expression in
diseases of protein folding. |
| Daniel Tracey |
Assistant Professor of Cell
Biology |
Isolation of genes required for sensory processing:
touch detection (mechanotransduction), heat detection
(thermotransduction), processing of RNA in neuronal
dendrites, animal behavior, nociception. |
| Raphael Valdivia |
Assistant Professor of Molecular
Genetics & Microbiology |
Endosome dynamics and microbial pathgenesis. |
| Antonius
VanDongen |
Associate Professor of Pharmacology
and Cancer Biology |
Physiological regulation and structure/function relationships
of ion channels. |
| Steven Vigna |
Associate Professor of Cell
Biology |
Gastrointestinal hormones and neuropeptides. |
| Rytas Vilgalys |
Professor of Biology |
Phylogenetic biology and natural history of fungi,
including molecular phylogeny and population genetics
of medically important species. |
| Fan
Wang |
Assistant Professor of Cell
Biology |
Neural circuit development in mouse somatic sensory
system. |
| Xiao-Fan
Wang |
Professor of Pharmacology
and Cancer Biology |
TGF-ß signaling mechanisms and animal model
systems; Tumor angiogenesis and metastasis; DNA damage
checkpoint. |
| Robert Wechsler-Reya |
Assistant Professor of Pharmacology
and Cancer Biology |
Role of Sonic Hedgehog Signaling in
Neural Development and Cancer. |
| Anne E. West |
Assistant Professor of Neurobiology |
Molecular Mechanisms of Neuronal Activity-dependent
Synapse Development |
| Robin Wharton |
Professor of Molecular
Genetics & Microbiology |
Molecular mechanism of pattern formation in the Drosophila embryo. |
| A. Richard Whorton |
Associate Professor of Pharmacology
and Cancer Biology |
Biochemistry and pharmacology of nitric oxide; cellular
redox staus and nitric oxide mediated cell signalling. |
| Fulton Wong |
Professor of Neurobiology |
Cellular mechanisms of retinal degeneration. |
| Jo Rae Wright |
Professor of Cell
Biology |
Innate host defense in the lung. Mechanisms of pathogen
subversion of lung host defense. |
| Tso-Pang
Yao |
Associate Professor of Pharmacology
and Cancer Biology |
Functional dissection of the role of protein acetylation
and deacetylation in signal transduction pathways,
particularly in the context of cancer formation. |
| Hai Yan |
Assistant Professor of Pathology |
Cancer genomics; Pathways that control tumorigenesis |
| Yiping Yang |
Assistant Professor of Immunology |
Innate immunity to viruses, Immune suppression by regulatory T cells and Formation of long-lived memory T cells. |
| John York |
Associate Professor of Pharmacology
and Cancer Biology |
Nuclear Inositol Signaling, Phosphatase Regulation
of Inositol Lipid Messengers, and Lithium Pharmacology. |
| Michael
Zalutsky |
Assistant Professor of Pathology |
Endoradiotherapeutics. |
| Weiguo Zhang |
Assistant Professor of Immunology |
Antigen receptor-mediated signaling; Lymphocyte development;
Mast cell function |
| Pei Zhou |
Assistant Professor of Biochemistry |
Biomolecular NMR; Protein Interactions; Molecular
Recognition; Conformation variability. |
| Yuan Zhuang |
Associate Professor of Immunology |
Transcriptional regulation of lymphocyte differentiation
and development. Animal models for autoimmune diseases. |
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