My research involves identifying and characterizing
gene regulatory elements across the genome to help
us understand how chromatin structure dictates cell
function and fate. For the last 25 years, mapping
DNase I hypersensitive sites has been the gold standard
method to identify the location of active regulatory
elements, including promoters, enhancers, silencers,
and locus control regions. I have developed two high-throughput
genome-wide technologies that can identify most DNase
I hypersensitive sites from potentially any cell
type from any species with a sequenced genome. These
data can be combined with other wet-lab and computational
data types to better understand how these regulatory
regions control global gene expression.
