The focus of research in our laboratory is the genomics
of fungi. Recent completion of the genomic sequence
of multiple fungal genomes makes it now possible to
identify mechanisms of gene regulation, mechanisms
of pathogenicity and to understand the wide diversity
of lifestyles and biochemical abilities among the
fungi. Through our role as a part of the Duke Center
for Genome Technology we are involved in the sequencing
of C. neoformans as well as the updating of the sequence
of S. cerevisiae. Also through the Center for Genome
Technology we are developing microarrays to characterize
the diversity of the C. neoformans population. The
goal is to characterize the diversity of both environmental
and clinical isolates to try to identify characteristics
important for pathogenicity.
