Dr. Haynes' laboratory studies the cellular and molecular
events that lead to normal human T-cell maturation
and disordered immunity in diseases such as congenital
and acquired immunodeficiency syndromes and rheumatoid
arthritis. The Haynes laboratory has developed techniques
for identifying the earliest precursors of the T-cell
lineage and, using monoclonal antibody technology,
has identified cell surface molecules of both thymocytes
and nonlymphoid components of the human thymic microenvironment
that are important in thymocyte-stromal cell interactions
and normal T-cell development. Using these and other
assay systems including cell sorting, cytokine and
V[[beta]] analysis by PT-PCR, targeted disruption
of murine genes, and cellular assays of immune cell
function, the Haynes laboratory is pursuing several
areas of research.
