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Cagla Eroglu

Associate Professor
Cell Biology
(919) 684-3605
Research Interest: 
Developmental biology
Signal transduction
Research Summary: 
Role of astrocytes in synaptic connectivity
Research Description: 

Elucidation of cellular and molecular mechanisms that regulate the formation and experience-dependent plasticity of neural circuits presents an ultimate challenge in basic neuroscience research, as these processes are believed to underlie cognition, learning and memory. Such insight is also crucial to understand the pathophysiology of highly prevalent neurological disorders including mental retardation, autism, depression and addiction. In my lab our goal is to uncover the mechanisms that control synaptogenesis in the central nervous system (CNS), which is an important first step in the formation of circuits. Our perspective includes astrocytes as an integral part of the glutamatergic synapse and explores astrocytic contribution to the formation, plasticity and function of excitatory synapses in the CNS.

Astrocytes Control Synapse Formation, Function, and Elimination.
Chung WS, Allen NJ, Eroglu C.
Cold Spring Harb Perspect Biol. 2015. 7:a020370.

Astrocytes refine cortical connectivity at dendritic spines.
Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Singh Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu C.
Elife. 2014. 3: .

Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
McKinstry SU, Karadeniz YB, Worthington AK, Hayrapetyan VY, Ozlu MI, Serafin-Molina K, Risher WC, Ustunkaya T, Dragatsis I, Zeitlin S, Yin HH, Eroglu C.
J Neurosci. 2014. 34:9455-72.

Neuroligins provide molecular links between syndromic and nonsyndromic autism.
Singh SK, Eroglu C.
Sci Signal. 2013. 6:re4.

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.
Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C, Workman G, Weaver M, Sage EH, Barres BA, Eroglu C.
Proc Natl Acad Sci U S A. 2011. 108:E440-9.