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Chris Counter

Pharmacology and Cancer Biology
(919) 684-9890
Research Interest: 
Signal transduction
Research Summary: 
Molecular analysis of Ras signaling in cancer
Research Description: 

The lab studies the molecular mechanisms underlying the evolution of normal cells into cancer, and in particular, the oncogene Ras. Ras is mutated in one quarter of all human cancers to promote cancer. The lab employs molecular and genetic approaches in vitro and in vivo to elucidate the roles of signalling pathways utilized by oncogenic Ras in cancer.

Tumour maintenance is mediated by eNOS.
Lim KH, Ancrile BB, Kashatus DF, Counter CM.
Nature. 2008. 452:646-9.

RALA and RALBP1 regulate mitochondrial fission at mitosis.
Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD, Counter CM.
Nat Cell Biol. 2011. 13:1108-15.

Rare codons regulate KRas oncogenesis.
Lampson BL, Pershing NL, Prinz JA, Lacsina JR, Marzluff WF, Nicchitta CV, MacAlpine DM, Counter CM.
Curr Biol. 2013. 23:70-5.

Copper is required for oncogenic BRAF signalling and tumorigenesis.
Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM.
Nature. 2014. 509:492-6.