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David McClay

Arthur S Pearse Professor of Biology
Biology
(919) 613-8188
Research Interest: 
Developmental biology
Signal transduction
Research Summary: 
We use systems level approaches to study control and execution of morphogenetic movements in sea urchin embryos.
Research Description: 

After fertilization cells of the embryo establish gene regulatory networks that progressively specify identities of all the cells of the organism. As this process proceeds the cells reach gastrulation where they engage in morphogenetic movements that constructs the primitive body plan. At a systems level the challenge in our lab is to understand specification of sea urchin embryos, a relatively simple model system that allows us to analyze the transcriptional control of morphogenesis. To date the gene regulatory networks we study are dynamic and composed of more than 100 transcription factors and a number of signal transductions that reflect a dynamic series of changes as cells diversify. The goal is to understand an epithelial-mesenchyme transition, homing of the primordial germ cells to their target tissue, invagination of the archenteron, movement of pigment cells, and formation of the skeleton. In each case an upstream gene regulatory network governs the downstream morphogenetic movement.

Publications: 
Delayed transition to new cell fates during cellular reprogramming.
Cheng X, Lyons DC, Socolar JE, McClay DR.
Dev Biol. 2014. 391:147-57.

Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition.
Saunders LR, McClay DR.
Development. 2014. 141:1503-13.

Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm.
McIntyre DC, Seay NW, Croce JC, McClay DR.
Development. 2013. 140:4881-9.

Hedgehog signaling requires motile cilia in the sea urchin.
Warner JF, McCarthy AM, Morris RL, McClay DR.
Mol Biol Evol. 2014. 31:18-22.

Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult.
Warner JF, Lyons DC, McClay DR.
PLoS Biol. 2012. 10:e1001404.