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Eda Yildirim

Assistant Professor
Cell Biology
(919) 668-0460
Research Interest: 
Cell cycle
Developmental biology
Research Summary: 
Epigenetic regulation and nuclear organization in mammalian development and disease.
Research Description: 

In the Yildirim lab, we are interested in understanding how the coding capacity and the functionality of the mammalian genome is fine-tuned by epigenetic factors and nuclear organization. We primarily use X-chromosome inactivation as a model to study how epigenetic mechanisms, particularly those that are mediated by long noncoding RNAs (lncRNAs), complement gene expression, impact genome stability and define cell fate decisions.

Other research in the lab focuses on understanding how spatial organization of the genome is achieved through interactions that are formed between chromatin and components of the nuclear envelope. Our goal is to define the molecular bases of these interactions and delineate their significance in driving gene expression and genome functions. We approach these two main areas of research by utilizing a variety of genetic, cell biological and genomics tools using mouse stem cells and mouse models. In the long run, a detailed understanding of the genetic, epigenetic, and cellular mechanisms that are mediated by lncRNAs and spatial positioning will allow us to explore their causal roles in disease and cancer.

Xist RNA is a potent suppressor of hematologic cancer in mice.
Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT.
Cell. 2013. 152:727-42.

Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci.
Sadreyev RI, Yildirim E, Pinter SF, Lee JT.
Proc Natl Acad Sci U S A. 2013. 110:6949-54.

X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription.
Yildirim E, Sadreyev RI, Pinter SF, Lee JT.
Nat Struct Mol Biol. 2012. 19:56-61.

Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations.
Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, Lee JT.
Genome Res. 2012. 22:1864-76.

The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
Yildirim E, Dietrich A, Birnbaumer L.
Proc Natl Acad Sci U S A. 2003. 100:2220-5.