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Jason Locasale

Assistant Professor
Pharmacology and Cancer Biology
(919) 684-9309
Research Interest: 
Enzymology
Nucleic acid metabolism
Signal transduction
Research Summary: 
Multidisciplinary approaches for studying metabolism and its contribution to disease, particularly cancer. A list of publications is found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=locasale+j
Research Description: 

Our efforts focus on two areas: 1.) Understanding basic biology of metabolic regulation of chromatin state. 2.) Defining the contexts in which targeting metabolism in cancer may be effective.

We study two pathways that interweave into both of these areas: 1.) Central carbon involving glycolysis and the citric acid cycle. 2.) Amino acid metabolism through serine, glycine, and one carbon metabolism.

There is an immediate clinical importance in studying these networks. Agents that target these networks are either 1.) currently being investigated for their merits as cancer drugs with some as far along as Phase III trials, 2.) readily available by prescription and are being considered for repurposing for cancer therapy and prevention, or 3.) currently used as frontline chemotherapies with mixed results but the determinants of their efficacy are not known.

Publications: 
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.
Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gómez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla SN, Locasale JW.
Cell Metab. 2015. : .

Serine, glycine and one-carbon units: cancer metabolism in full circle.
Locasale JW.
Nat Rev Cancer. 2013. 13:572-83.

Characterization of the usage of the serine metabolic network in human cancer.
Mehrmohamadi M, Liu X, Shestov AA, Locasale JW.
Cell Rep. 2014. 9:1507-19.

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.
Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW.
Elife. 2014. 3: .

Development and quantitative evaluation of a high-resolution metabolomics technology.
Liu X, Ser Z, Locasale JW.
Anal Chem. 2014. 86:2175-84.