The mechanisms of organ and tissue formation during development
Our overall research interest is the regulation of organ development, and using the insights from this research to better understand human disease and to inform future therapeutic strategies. Our experiments address the molecular and cellular mechanisms that generate organs from pluripotent progenitor cells, using genetics and embryology as key approaches. Much of our work centers on the roles of intercellular signaling pathways, particularly Bone Morphogenetic Protein (BMP) and Hedgehog signaling. We primarily use the mouse model system, but use zebrafish, chick and cell culture as complementary tools.