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Madan Kwatra

Associate Professor
Clinical Sciences
(919)681-4775
Research Interest: 
Molecular structure
Neurobiology
Signal transduction
Research Summary: 
Research Summary (one sentence) This laboratory focuses on targeting the neurokinin-1 receptor in glioblastomas and understanding the molecular basis of postoperative delirium.
Research Description: 

This laboratory currently focuses on two topics: 1) Targeting the neurokinin-1 receptor in glioblastomas; and 2) Understanding the molecular basis of postoperative delirium. For the project on NK1 receptors in glioblastomas, we are using glioblastoma stem cells and glioblastoma xenografts as models to evaluate the feasibility of targeting NK1 receptors as a means to halt the growth of glioblastomas. These studies involve state-of-the art genomics and proteomics approaches. The project on postoperative delirium examines the roles of sleep apnea and insulin growth factor-1 in delirium pathophysiology. These clinical/basic science studies are conducted by enrolling patients undergoing elective knee replacement surgery and analyzing the relationship between patient histories of sleep apnea or lowered levels of insulin growth factor-1 and incidence of postoperative delirium.

Publications: 
Prevention of intraoperative awareness.
Kwatra MM.
N Engl J Med. 2011. 365:2033; author reply 2034-5.

Flaws in the serum anticholinergic activity assay: implications for the study of delirium.
Cox EA, Kwatra SG, Shetty S, Kwatra MM.
J Am Geriatr Soc. 2009. 57:1707-8.

A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.
Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, Sampson JH, Kwatra MM.
J Neurochem. 2009. 109:1079-86.

Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
Yamaguchi K, Richardson MD, Bigner DD, Kwatra MM.
Cancer Chemother Pharmacol. 2005. 56:585-93.

Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize.
Richardson MD, Balius AM, Yamaguchi K, Freilich ER, Barak LS, Kwatra MM.
J Neurochem. 2003. 84:854-63.