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Matthew Hirschey

Assistant Professor
Pharmacology and Cancer Biology
(919) 479-2315
Research Interest: 
Signal transduction
Research Summary: 
Mitochondrial function and small metabolite regulation of nutrient metabolism by post-translational modifications.
Research Description: 

The Hirschey Lab in the Departments of Medicine and Pharmacology & Cancer Biology and the Sarah W. Stedman Nutrition & Metabolism Center at Duke University explores different aspects of the biology of mitochondrial energy production, a crucial cellular process gaining recognition as an important regulator of human health and disease.

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y.
Cell Metab. 2014. 19:605-17.

Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylases.
Hirschey MD.
Cell Metab. 2011. 14:718-9.

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV, Kahn CR, Verdin E.
Mol Cell. 2011. 44:177-90.

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR.
Proc Natl Acad Sci U S A. 2011. 108:14608-13.

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E.
Nature. 2010. 464:121-5.