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Matthias Gromeier

Associate Professor
Clinical Sciences
Research Interest: 
Cell cycle
Microbiology and virology
Signal transduction
Research Summary: 
Mechanisms of protein synthesis regulation and ways to exploit abnormal signal transduction to translation machinery for cancer treatment.
Oncolytic poliovirus against malignant glioma.
Goetz C, Dobrikova E, Shveygert M, Dobrikov M, Gromeier M.
Future Virol. 2011. 6:1045-1058.

Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.
Wang ES, Dobrikova E, Goetz C, Dufresne AT, Gromeier M.
J Virol. 2011. 85:5606-17.

Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Dobrikov M, Dobrikova E, Shveygert M, Gromeier M.
Mol Cell Biol. 2011. 31:2947-59.

Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
Shveygert M, Kaiser C, Bradrick SS, Gromeier M.
Mol Cell Biol. 2010. 30:5160-7.

Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.
Walters RW, Bradrick SS, Gromeier M.
RNA. 2010. 16:239-50.