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Matthias Gromeier

Associate Professor
Clinical Sciences
919-668-6205
Research Interest: 
Cell cycle
Microbiology and virology
Signal transduction
Research Summary: 
Mechanisms of protein synthesis regulation and ways to exploit abnormal signal transduction to translation machinery for cancer treatment.
Publications: 
Oncolytic poliovirus against malignant glioma.
Goetz C, Dobrikova E, Shveygert M, Dobrikov M, Gromeier M.
Future Virol. 2011. 6:1045-1058.

Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.
Wang ES, Dobrikova E, Goetz C, Dufresne AT, Gromeier M.
J Virol. 2011. 85:5606-17.

Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Dobrikov M, Dobrikova E, Shveygert M, Gromeier M.
Mol Cell Biol. 2011. 31:2947-59.

Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.
Shveygert M, Kaiser C, Bradrick SS, Gromeier M.
Mol Cell Biol. 2010. 30:5160-7.

Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.
Walters RW, Bradrick SS, Gromeier M.
RNA. 2010. 16:239-50.