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Nancy Andrews

Dean, School of Medicine & Professor
Clinical Sciences
(919) 684-2455
Research Interest: 
Developmental biology
Research Summary: 
Mammalian iron homeostasis and human iron diseases
Research Description: 

Iron is important in many biological reactions, but excess iron causes cellular damage. The Andrews Lab is interested in disorders of mammalian iron homeostasis, including iron deficiency, anemia of chronic disease and hereditary hemochromatosis. We use a genetic approach to learn about the physiology of iron homeostasis. We take advantage of strong similarities in human and mouse iron biology, and use mouse genetics as a tool to characterize the roles of individual proteins in networks regulating iron transport and iron balance. Many of the mouse mutants that we have developed provide faithful models of human iron disorders.

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.
Finberg KE, Whittlesey RL, Fleming MD, Andrews NC.
Blood. 2010. 115:3817-26.

Forging a field: the golden age of iron biology.
Andrews NC.
Blood. 2008. 112:219-30.

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).
Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD.
Nat Genet. 2008. 40:569-71.

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC.
Cell Metab. 2008. 7:205-14.

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.
Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC.
Cell Metab. 2005. 1:191-200.