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Nicole Calakos

Associate Professor
Research Interest: 
Research Summary: 
Molecular mechanisms of synaptic plasticity; presynaptic function; basal ganglia function and pathology
Research Description: 

We study the molecular mechanisms for long-term synaptic plasticity and the behavioral significance of this process in basal ganglia disorders. We draw upon diverse technical approaches that include synaptic electrophysiology, mouse genetic models, acute molecular manipulations of activity in vivo, and behavioral assays.

MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.
Deng JV, Wan Y, Wang X, Cohen S, Wetsel WC, Greenberg ME, Kenny PJ, Calakos N, West AE.
J Neurosci. 2014. 34:4519-27.

A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities.
Dufour S, Lavertu G, Dufour-Beauséjour S, Juneau-Fecteau A, Calakos N, Deschênes M, Vallée R, De Koninck Y.
PLoS One. 2013. 8:e57703.

Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder.
Wan Y, Ade KK, Caffall Z, Ilcim Ozlu M, Eroglu C, Feng G, Calakos N.
Biol Psychiatry. 2014. 75:623-30.

A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL.
Neuropsychopharmacology. 2013. 38:854-62.

Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
Wan Y, Feng G, Calakos N.
J Neurosci. 2011. 31:16685-91.