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Faculty Directory - Signal transduction

Professor, Departments of Pathology, Immunology and Molecular Genetics & Microbiology
Pathology
Host-pathogen cross talk and mast cell modulation of innate and adaptive immune responses
9196843630
Professor in Medicine, and Associate Professor in MGM
Molecular Genetics and Microbiology
Intracellular signaling pathways that are activated in pathogenic microorganisms and allow survival in the host.
(919) 684-0045
Assistant Professor
Pharmacology and Cancer Biology
Intratumor heterogeneity and its contribution to tumor progression using mouse models.
(919) 681-5479
Professor
Pharmacology and Cancer Biology
Mechanisms of signal transduction and intracellular protein sorting in photoreceptor cells; photoreceptor pathobiology; neurobiology of the retina.
(919) 668-5391
Associate Professor of Biology
Biology
Drosophila as a model system to understand Wnt signal transduction and epidermal cell patterning.
(919) 613-8162
Associate Professor
Pharmacology and Cancer Biology
The role of transforming growth factor-beta (TGF-beta) superfamily signaling pathways in cancer biology.
(919) 668-1352
Assistant Professor of Biochemistry
Biochemistry
Cell signaling through protein glycosylation, using chemical, biochemical and cell biological methods.
(919) 684-9906
Assistant Professor
Biology
The evolution of gene networks using a systems biology approach.
(919) 699-8209
Research Professor
Molecular Genetics and Microbiology
Nutrient sensing and control of cell growth; relevant to immunosuppressive, anticancer, and fungicidal drug action.
(919) 684-2095
James B. Duke Professor
Cell Biology
Molecular and cellular mechanisms by which G protein-coupled receptors control normal and abnormal physiological functions.
919-684-5433
Assistant Professor
Biology
Light signaling and nuclear organization in plants
(919) 684-8442
Professor
Pharmacology and Cancer Biology
Molecular analysis of Ras signaling in cancer
(919) 684-9890
Associate Professor, Director DUHS Clinical Molecular Diagnostics Laboratory
Pathology
Development of multigene assays to determine cancer patient-specific prognoses.
(919) 684-2698
Associate Professor
Application of high-throughput technologies in conjunction with traditional experimental methods to better understand the biology of cancers.
(919)681-1912
Associate Professor
Clinical Sciences
Cancer Biology, including regulation of apoptosis in therapeutic resistance, tumor-immune microenvironment, growth factor receptors, and genomics
919 668 0410
Associate Professor
Cell Biology
Role of astrocytes in synaptic connectivity
(919) 684-3605
Associate Professor
Clinical Sciences
Intracellular signaling and protein-organelle trafficking in health and disease
(919)684-8457
Assistant Professor
Pharmacology and Cancer Biology
Regulation of primary cilia and their role in development and human disease.
(919) 684-3529
Assistant Professor
Neurobiology
Molecular mechanisms of nociception, specifically the mechanisms of sensory ion channels involved in sensing temperature and touch.
(919) 684-1144
Associate Professor
Clinical Sciences
Mechanisms of protein synthesis regulation and ways to exploit abnormal signal transduction to translation machinery for cancer treatment.
919-668-6205
Assistant Professor
Immunology
Signaling pathways that govern how dendritic cells interact with microbial commensals in the intestine.
(919) 660-9003
Associate Professor
Pharmacology and Cancer Biology
Smooth and striated muscle plasticity in response to physiological stress, drug discovery in obesity, and drug discovery in infectious diseases.
919-613-8606
James B. Duke Professor and Chair
Molecular Genetics and Microbiology
How cells sense and respond to their environments; molecular mechanisms of sex determination and the impact of sexual reproduction on evolution and microbial virulence
(919) 684-2824
Associate Professor in Orthopaedic Surgery and Cell Biology
Cellular and molecular mechanisms that regulate skeletal development, disease, and repair or regeneration.
(919) 613-9761
Assistant Professor
Pharmacology and Cancer Biology
Mitochondrial function and small metabolite regulation of nutrient metabolism by post-translational modifications.
(919) 479-2315
Professor and Chair
Cell Biology
Organogenesis and stem cells
919-684-8085
Assistant Professor of Orthopaedic Surgery and Cell Biology
The role and molecular regulation of cellular metabolism during musculoskeletal development and disease.
(919) 668.5664
Associate Dean, Graduate School and Associate Professor
Cell Biology
The mechanisms of organ and tissue formation during development
Provost of Duke University and James B Duke Professor
Pharmacology and Cancer Biology
The basic biology of programmed cell death (apoptosis) and cell cycle progression as well as the potential for modulating these signaling pathways to enhance cancer therapy.
919 668 4729
Professor of Medicine; Assistant Professor Cell Biology
Clinical Sciences
Molecular mechanisms whereby skeletal muscle adaptation mediate the health benefits of exercise training.
(919) 681-6733
Professor
Pharmacology and Cancer Biology
Reciprocal interactions of hormones, monoamine neuron function, and psychiatric diseases, especially addiction and depression, in animal models.
919-684-8828
Associate Professor
Clinical Sciences
Research Summary (one sentence) This laboratory focuses on targeting the neurokinin-1 receptor in glioblastomas and understanding the molecular basis of postoperative delirium.
(919)681-4775
James B. Duke Professor of Medicine
Biochemistry
Molecular properties and regulatory mechanisms that control the function of plasma membrane receptors for hormones and drugs.
(919) 684-2974
James B. Duke Professor
Pharmacology and Cancer Biology
Control of cell polarity and its relation to the cell cycle in yeast.
(919) 613-8627
Professor of Dermatology, Cancer Biology and Pharmacology
Clinical Sciences
Novel roles of caspases in regulating stemness, epigenetic cellular plasticity, and tumor response to radiation therapy and chemotherapy.
(919) 613-8754
Assistant Professor of Immunology
Immunology
microRNA regulation during the T cell development and differentiation
9196684070
Associate Professor Pediatrics,
Pharmacology and Cancer Biology
Mechanisms of sarcomagenesis; senescence; modeling cancer from primary human cells.
(919) 681-3508
Assistant Professor
Clinical Sciences
Autophagy lysosomal pathway in ocular physiology and pathophysiology.
(919) 681 4085
Assistant Professor
Pharmacology and Cancer Biology
Multidisciplinary approaches for studying metabolism and its contribution to disease, particularly cancer. A list of publications is found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=locasale+j
(919) 684-9309
Associate Professor
Molecular Genetics and Microbiology
Mechanisms of viral oncogenesis and host response to oncogenic virus infection
919-668-3091
Associate Professor
Biology
Understanding how genetic variation affects signal transduction and gene regulatory networks, and how in turn variation in such networks affects cellular phenotypes.
(919) 613-8159
Assistant Professor of Ophthamology
Clinical Sciences
Molecular mechanisms and signaling pathways underlying retinal diseases including age-related macular degeneration and diabetic retinopathy.
(919) 684 0820
Associate Professor
Clinical Sciences
The etiology of human breast and ovarian cancer.
9196846133
Research Professor
Pharmacology and Cancer Biology
The central focus of the lab is to understand signaling pathway architecture
Professor
Molecular Genetics and Microbiology
Molecular mechanisms of smell and other chemical senses
(919) 684-2777
Arthur S Pearse Professor of Biology
Biology
Systems level approaches to study control and execution of morphogenetic movements in sea urchin embryos.
(919) 613-8188
Glaxo-Wellcome Professor of MCB and Chair
Pharmacology and Cancer Biology
Identification of druggable targets within estrogen- and androgen-regulated signal transduction pathways that can be exploited in the development of novel breast and prostate cancer therapeutics.
(919) 684-6035
Assistant Professor of Orthopaedic Surgery & Pathology
Development of strategies to prevent osteoarthritis and promote tissue repair and regeneration following joint injury. Understanding the mechanotransduction pathways that modulate cartilage and meniscus homeostasis and how these signaling pathways are altered with aging and pathology to reveal potential targets to prevent joint tissue degeneration and osteoarthritis.
(919) 684-6882
Professor
Biochemistry
Physical chemistry of biological macromolecules: kinetics, thermodynamics, spectroscopy and structure.
919 684-4363
Professor and Vice Chair, Pharmacology & Cancer Biology
Pharmacology and Cancer Biology
Regulation of cellular signaling networks by tyrosine kinases in development and cancer.
919-681-8086
Professor of Medicine and Director, Ion Channel Research Unit
Neurobiology
Ion channel structure, function, and physiology in normal and disease states.
(919)668-7641
Edward S. Orgain Professor of Cardiology
Clinical Sciences
Molecular mechanisms of cardiac hypertrophy and heart failure
919-668-2520
Associate Professor of Biomedical Engineering
Using systems biology to study spatiotemporal controls of multicellular systems, and how their subversion lead to diseases.
(919) 681-9184
Associate Professor in Medicine, Assistant Professor in Cell Biology
Dynamics and functional roles of post-translational modifications of seven-transmembrane G protein-coupled receptors and β-arrestins.
(919) 681-5061
Associate Professor
Biology
Cell invasion through extracellular matrix, stem cell-niche interactions, cellular pausing
919-684-8658
Assistant Professor
Immunology
Innate immunity impacts on adaptive immunity during development of diseases, such as cancer, infections, and autoimmune diseases.
(919)613-6977
Associate Professor
Cell Biology
Regulation of the cytoskeleton during normal neural development and its linkage to intellectual disability, autism, and schizophrenia.
919-452-9231
Professor of Biology
Biology
Molecular genetics of growth hormone-mediated plant development.
(919) 613-8166
Assistant Professor
Cell Biology
Understanding the cellular and molecular basis of cell plasticity in organ regeneration and tumorigenesis.
(919) 684-0624
Professor
Pharmacology and Cancer Biology
Regulation of stress-responsive gene expression and roles of metals in growth, development, signaling and microbial pathogenesis
919-684-5776
Assistant Professor of Medicine and Immunology
How the cholesterol biosynthesis pathway regulates innate and adaptive immune responses and its implication in autoimmune, inflammatory diseases.
(919) 684-5586
Donald and Elizabeth Cooke Professor of Experimental Oncology
Pharmacology and Cancer Biology
Molecular nature and signaling mechanism of tumor microenvironment associated with tumor progression and metastasis.
919-681-4861
Associate Professor of Neurobiology
Neurobiology
Mechanisms and consequences of stimulus-regulated transcription in the central nervous system.
(919)681-1909
Assistant Professor
Pharmacology and Cancer Biology
New functional genomics technologies and their applications in basic and translational cancer biology
(919) 613-8634
Associate Professor
Immunology
Adaptor proteins in immunoreceptor-mediated signaling, cellular activation, and development of autoimmunity
(919)613-7803
Associate Professor of Pediatrics
Clinical Sciences
Signal transduction in the immune system and control of immune cell development and function.
(919) 681-9450