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Robert Lefkowitz

James B. Duke Professor of Medicine
(919) 684-2974
Research Interest: 
Molecular structure
Signal transduction
Research Summary: 
Molecular properties and regulatory mechanisms that control the function of plasma membrane receptors for hormones and drugs.
Research Description: 

The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Studies are performed with isolated protein, whole cells in culture and even in vivo in whole animals.