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Ryan Baugh

Assistant Professor
(919) 613-8179
Research Interest: 
Developmental biology
Nucleic acid metabolism
Research Summary: 
Nutritional control of C. elegans development
Research Description: 

We study nutritional control of development in the model system Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that govern cellular quiescence and growth in response to nutrient availability. Life in the wild is characterized by feast or famine for this free-living nematode, and we are taking advantage of the rich resources and developmental context it provides for our research.

Pol II docking and pausing at growth and stress genes in C. elegans.
Maxwell CS, Kruesi WS, Core LJ, Kurhanewicz N, Waters CT, Lewarch CL, Antoshechkin I, Lis JT, Meyer BJ, Baugh LR.
Cell Rep. 2014. 6:455-66.

WormSizer: high-throughput analysis of nematode size and shape.
Moore BT, Jordan JM, Baugh LR.
PLoS One. 2013. 8:e57142.

Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans.
Maxwell CS, Antoshechkin I, Kurhanewicz N, Belsky JA, Baugh LR.
Genome Res. 2012. 22:1920-9.

Metazoan operons accelerate recovery from growth-arrested states.
Zaslaver A, Baugh LR, Sternberg PW.
Cell. 2011. 145:981-92.

RNA Pol II accumulates at promoters of growth genes during developmental arrest.
Baugh LR, Demodena J, Sternberg PW.
Science. 2009. 324:92-4.