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Thomas Tedder

Alter E. Geller Professor for Research in Immunology
(919) 684-3681
Research Interest: 
Research Summary: 
B lymphocyte function and the structure of cell surface molecules that regulate B cell function, activation and signal transduction.
Research Description: 

The laboratory is primarily focused on the role of B lymphocytes in human disease, including autoimmunity and tumor immunology. Specifically, we focus on the identification and biochemical/structural characterization of cell surface molecules found primarily on B lymphocytes in order to determine how these molecules function, what their ligands are, and how they generate transmembrane signals to regulate B cell function. This information guides studies examining how normal B cells influence T cell function, autoimmunity, and host responses to pathogens and tumors. Most recently, our studies have centered on the identification and characterization of a subset of regulatory B cells with the capacity to produce IL-10 that we call B10 cells. This tiny B cell subset is a major regulatory of immune system homeostasis and function. Specifically, both human and mouse B10 cells regulate innate, humoral and cellular immunity during inflammation, autoimmunity and lymphoma. The findings from these collective studies have allowed us to identify ways that B lymphocytes, their surface molecules and drugs targeting these cells can be used for the treatment of autoimmunity and B cell malignancies. As an example, one drug developed in our laboratory is currently in international phase II clinical trails for the treatment of autoimmunity and non-Hodgkin’s lymphoma.

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.
Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, Szabolcs PM, Bernstein SH, Magro CM, Williams AD, Hall RP, St Clair EW, Tedder TF.
Blood. 2011. 117:530-41.

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF.
Immunity. 2008. 28:639-50.

Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.
Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, Matsushita T, Tedder TF.
PLoS One. 2011. 6:e22464.

Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.
Horikawa M, Minard-Colin V, Matsushita T, Tedder TF.
J Clin Invest. 2011. 121:4268-80.

B10 cell regulation of health and disease.
Candando KM, Lykken JM, Tedder TF.
Immunol Rev. 2014. 259:259-72.