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Yong-hui Jiang

Assistant Professor
Research Interest: 
Developmental biology
Research Summary: 
Genetic and epigenetic basis of neurodevelopmental disorders
Research Description: 

The research in Jiang’s lab is directed at understanding genetic and epigenetic basis of human diseases with a focus on genomic imprinting disorders of Angelman and Prader-Willi syndrome as well as autism spectrum disorders. As a physician scientist, Dr. Jiang is particularly interested in modeling the human diseases in mouse models and the transitional potential in humans
Project 1: Identify molecular basis of autism spectrum disorders using cutting-edge genomic and epigenetic analysis.
Project 2. Model the human neurodevelopmental disorder including autism, Angelman and Prader-Willi syndrome in mutant mice. Using techniques combining biochemical, morphological, electrophysiological, and behavioral analysis, we are dissecting the function of human disease causing genes and understanding the disease pathogenesis.
Project 3. Understand the role of epigenetics in brain function. Using mutant mouse model, we are studying the role of DNA methylation and hydroxymethylation in regulating the synaptic genes in brains and their relevance in human diseases.

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.
Wang X, McCoy PA, Rodriguiz RM, Pan Y, Je HS, Roberts AC, Kim CJ, Berrios J, Colvin JS, Bousquet-Moore D, Lorenzo I, Wu G, Weinberg RJ, Ehlers MD, Philpot BD, Beaudet AL, Wetsel WC, Jiang YH.
Hum Mol Genet. 2011. 20:3093-108.

Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.
Jiang YH, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, Lorenzo I, Brilliant M, Noebels J, Beaudet AL.
PLoS One. 2010. 5:e12278.

Epigenetics and human disease.
Jiang YH, Bressler J, Beaudet AL.
Annu Rev Genomics Hum Genet. 2004. 5:479-510.

A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A.
Jiang YH, Sahoo T, Michaelis RC, Bercovich D, Bressler J, Kashork CD, Liu Q, Shaffer LG, Schroer RJ, Stockton DW, Spielman RS, Stevenson RE, Beaudet AL.
Am J Med Genet A. 2004. 131:1-10.

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.
Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G, Sweatt JD, Beaudet AL.
Neuron. 1998. 21:799-811.