Our interest centers on the molecular mechanisms
by which components of signal transduction pathways
are organized into specialized membrane domains. In
addition to their known role in organizing receptors
and downstream effectors into functional signaling
complexes, such organized complexes function to integrate
signaling activities from multiple pathways and to
segregate simultaneous but distinct functions of a
single pathway. We study this question in Drosophila
because of the utility of this system for studying
the functions of individual genes, and for examining
the functional interactions between different genes
that work together in a particular cellular or developmental
process. Trainees participate in most aspects of this
research in the course of their dissertation research.
