Dr. Lo is Co-Director of the new Center for Drug
Discovery at Duke, which focuses on the translation
of basic neuroscience research into the identification
of new drug candidates and targets for neuropsychiatric
diseases including Alzheimer's disease, Huntington's
disease, stroke, and glaucoma. In this context, the
Center has developed a series of discovery technologies,
based on high-content screening and chemical genetics,
to drive towards the efficient identification of new
neurological drug candidates with improved likelihood
of clinical success. Much of this work has been based
on more than a decade of research into the functional
roles of neurotrophin signaling in establishing and
modulating the form and function of neurons and neural
circuits within the central nervous system, and on
the development of novel technologies for gene transfer
into intact neural tissues.
