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Dennis J. Thiele

Professor
Pharmacology and Cancer Biology
919-684-5776
Research Interest: 
Genetics
Microbiology and virology
Signal transduction
Research Summary: 
Regulation of stress-responsive gene expression and roles of metals in growth, development, signaling and microbial pathogenesis
Research Description: 

Our laboratory seeks to decipher how organisms regulate their growth, development and proliferation through establishing and maintaining proper homeostatic control mechanisms. We are interested in understanding how stress-responsive genes are activated and how the encoded proteins function in the prevention of disease states caused by protein misfolding such as neurodegenerative disease. We are also interested in how organisms transport and distribute the essential elements copper and iron, and properly regulate gene expression in response to these metals for normal growth and development and in microbial infection.

Publications: 
Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.
Neef DW, Jaeger AM, Thiele DJ.
Nat Rev Drug Discov. 2011. 10:930-44.

Copper in microbial pathogenesis: meddling with the metal.
Samanovic MI, Ding C, Thiele DJ, Darwin KH.
Cell Host Microbe. 2012. 11:106-15.

Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.
Kim BE, Turski ML, Nose Y, Casad M, Rockman HA, Thiele DJ.
Cell Metab. 2010. 11:353-63.

Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.
Neef DW, Turski ML, Thiele DJ.
PLoS Biol. 2010. 8:e1000291.

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99.
Ding C, Yin J, Tovar EM, Fitzpatrick DA, Higgins DG, Thiele DJ.
Mol Microbiol. 2011. 81:1560-76.