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Kate Meyer

Assistant Professor
(919) 684-9562
Research Interest: 
Nucleic acid metabolism
Research Summary: 
We study mRNA modifications and their role in nervous system function.
Research Description: 

The Meyer lab has a long-standing interest in RNA regulatory pathways that contribute to gene expression control in the cell. Our primary focus is on N6-methyladenosine, or m6A, which is an RNA base modification that occurs when adenosine residues become methylated. We and others have recently discovered that m6A is present in thousands of cellular mRNAs and that it is particularly abundant within the brain. However, the function of m6A is still poorly understood. Studies in the lab seek to understand how m6A is regulated within the cell and how it controls gene expression. We are especially interested in exploring m6A-mediated regulatory pathways in the nervous system and in elucidating how RNA methylation contributes to neurodevelopment, learning and memory, and neurodegenerative disease.

5' UTR m(6)A Promotes Cap-Independent Translation.
Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB, Jaffrey SR.
Cell. 2015. 163:999-1010.

The dynamic epitranscriptome: N6-methyladenosine and gene expression control.
Meyer KD, Jaffrey SR.
Nat Rev Mol Cell Biol. 2014. 15:313-26.

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC.
Nat Neurosci. 2013. 16:1042-8.

Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR.
Cell. 2012. 149:1635-46.

Novel RNA modifications in the nervous system: form and function.
Satterlee JS, Basanta-Sanchez M, Blanco S, Li JB, Meyer K, Pollock J, Sadri-Vakili G, Rybak-Wolf A.
J Neurosci. 2014. 34:15170-7.