Regulation of the cytoskeleton during normal neural development and its linkage to intellectual disability, autism, and schizophrenia.
My laboratory is interested in two broad questions. 1) How is Rho-family GTPase signaling to the actin cytoskeleton in neurons regulated by multi-protein complexes? 2) How does the organization of these signaling pathways translate to the regulation of normal neuronal function or disorders such as intellectual disability, schizophrenia, or autism?
To answer these questions our laboratory utilizes a combination of mouse genetics, proteomics, cellular imaging, and behavioral analysis.